Abstract: This paper presents a trend analysis of Mann-Kendal (M-K) coupled with a persistence analysis of rescaled range analysis (R/S) on the changes in meteorological factors to better understand the temporal and spatial distribution characteristics of future water resources changes in the Yellow River basin. The results show that for the middle reach of the river in future, on an annual average, water supply will have an optimistic outlook in its southern region (an area proportion of 5.36%) while the risk in water shortage will increase in the central region (29.42%). In different seasons of a year, the spatial distribution of water supply will be significantly different. Along with seasonal change from spring to winter, both the central and southern regions are becoming increasingly more humid, while the northern region increasingly more arid. In addition, the areas with the same water supply conditions are relatively concentrated.